Labeled nucleotides are a class of critical reagents in life science research and serve as effective tools for detecting and labeling specific nucleic acid sequences in molecular biology studies. Typically, labeled nucleotides are inserted into DNA or RNA sequences via enzymatic reactions to enable detection and analysis. Among non-radioactive labeling substances for DNA/cDNA probes, fluorophores and haptens are the most commonly used.

Nick translation is the method of choice for generating labeled DNA probes (100–500 bp) from genomic DNA, plasmids, BAC clones, and other templates. It relies on the coordinated action of DNase I (which introduces random single-strand breaks called "nicks") and DNA polymerase I. At these "nick" sites, DNA polymerase I incorporates labeled dUTP instead of its natural counterpart, dTTP, thereby producing optimal probes for in situ hybridization.

XMJ distributes a comprehensive range of DNA/cDNA labeling products from the brand Jena Bioscience, including fluorescently labeled and hapten-labeled options, as shown in the table below:

Fluorescent Nick Translation Labeling Kits

Biotin & Digoxigenin Nick Translation Labeling Kits

Beijing XMJ Technology Co., Ltd. is the authorized distributor of Jena Bioscience in China, providing customers with comprehensive technical support and after-sales service. For inquiries, please call Ximeijie’s customer service hotline at 400-050-4006 or visit our official website.

Jena Bioscience, distributed by Ximeijie, was co-founded in 1998 by renowned molecular biologists from the Max Planck Institute (MPI) in Germany. The company is dedicated to supplying a wide range of reagents and raw materials to scientific research institutions, hospitals, pharmaceutical enterprises, and diagnostic kit manufacturers worldwide. Its product portfolio includes specialty labeled nucleotides/nucleosides, labeled fluorescent probes, click chemistry reagents, protein crystallization products, and more. Jena Bioscience has obtained DIN EN ISO 9001, DIN EN ISO 14001, and EMAS certifications, and its product quality is recognized by customers in over 80 countries.

Brand Advantages

· Specialized products: Focus on nucleosides and nucleotide analogs as core competitive products.

· Comprehensive product range: Covering nucleosides, nucleotides and their analogs, proteins and protein expression systems, click chemistry reagents, reagents for biomacromolecular structure research, and reagents for molecular biology and biochemistry.

· Customization capability: A strong technical team providing high-quality customized services.

· Reliable quality assurance: Products certified by multiple international standards.

· Global recognition: Products and services trusted by customers in more than 80 countries.

Main Product Categories

1. Nucleosides & Nucleotide Analogs: Labeled nucleotides, deoxy/dideoxyribonucleotides, nucleotide analogs.

2. Click Chemistry: Nucleotides, fluorophores, biotin, ATP analogs, etc., conjugated with clickable groups.

3. Protein Structure-Related Products: Protein crystallization condition screening kits, protein crystallization consumables.

4. Molecular Biology: PCR kits (meeting various requirements) and single-component PCR products, DNA LEADER, restriction endonucleases, TAE buffer, TBE buffer.